ARoleforSerotonin(-HT)inHepaticStellateCellFunctionandLiverFibrosis
...icalandneurotrophicfactors.Thisstudyaddressesthepotentialfortheserotonin(5-HT)systemtoinfluenceHSCbiology.RatandhumanHSCsexpressthe5-HT1B,5-HT1F5-HT2A5-HT2B,and5-HT7receptors,withexpressionof5-HT1B5-HT2Aand5-HT2BbeinginducedonHSCactivation.Inductionof5-HT2Aand5-HT2Bwas106??39-and52??8.5-foldthatofqu...
医源资料库;在线期刊;美国病理学杂志;2006年第168卷第9期TheNaturalMutationEncodingaCTerminus-Truncated5-Hydroxytryptamine2BReceptorIsaGainofProliferativeFunctions
...ions,fewfunctionalmutationshavebeenidentifiedinthehuman5-hydroxytryptamine(HT)2Breceptorgene.AheterozygousmutationR393Xinthe5-HT2Breceptorwasrecentlyidentifiedinapatientdiagnosedwithpulmonaryhypertensionafterintakeoftheanorexigenicdexfenfluramine.Althoughreportedtogeneratealackoffunction,thisCtermin...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第4期Serotonin5-Hydroxytryptamine2CReceptorSignalinginHypothalamicProopiomelanocortinNeurons:RoleinEnergyHomeostasisinFemales
...mitterreceptorsignalingpathwaysconvergetocontrolenergyhomeostasis.Because5-HT2CreceptorsmediatemanyoftheeffectsofserotonininPOMCneurons,weelucidatedthecommonsignalingpathwaysofE2and5-HTinguineapigsusingsingle-cellreversetranscription-polymerasechainreaction(RT-PCR),realtimeRT-PCR,andwhole-cellpatchr...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第10期Palmitoylationofthe5-Hydroxytryptamine4aReceptorRegulatesReceptorPhosphorylation,Desensitization,and-Arrestin-MediatedEndocytosis
...,Montpellier,France(A.D.,F.G.,G.B.)AbstractThemouse5-hydroxytryptamine4a(5-HT4a)receptorisanunusualmemberoftheGprotein-coupledreceptorsuperfamilybecauseitpossessestwoseparatecarboxyl-terminalpalmitoylationsites,whichmayallowthereceptortoadoptdifferentconformationsinanagonist-dependentmanner(JBiolChe...
医源资料库;在线期刊;分子药理学杂志;2005年第67卷第5期5-HT1A受体的作用及其临床意义
【关键词】5-HT1A受体 5-羟色胺再摄取抑制剂(SSRI)是近十余年临床广泛应用的抗抑郁剂,有疗效好、不良反应轻和服药简便等多方面的优点,但在应用过程中也有起效较慢的缺点,特别是在抑郁症状严重需尽快解除时更显得...
医源资料库;在线期刊;四川精神卫生;2006年第19卷第3期NativeRatHippocampal5-HT1AReceptorsShowConstitutiveActivity
...关键词】NativePreviousstudieshaveshownthathuman5-hydroxytryptamine(5-HT)1AreceptorsstablyexpressedintransfectedcelllinesshowconstitutiveG-proteinactivity,asrevealedbytheinhibitoryeffectofinverseagonists,suchasspiperone,onbasalguanosine-5‘-O-(3-[35S]thio)-triphosphate([35S]GTPS)binding.Inthepre...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第3期5-HT细胞移植对慢性不可预见性抑郁症大鼠多器官损伤的作用与可能性机制
【摘要】目的探讨外源性5-HT神经细胞移植对慢性不可预见性应激大鼠多内脏器官损伤的作用。方法将40只雄性SD大鼠(购置第二军医大学实验动物中心)随机分为4组(10只/组):正常对照组(Ⅰ)、慢性应激组(Ⅱ)、慢性应激...
医源资料库;在线期刊;中华医学研究杂志;2007年第7卷第4期国际高血压防治指南对高血压定义、分层、诊断性评价的建议
【摘要】本文根据近年发表的国际高血压(HT)指南资料,对HT的流行病学情况,定义,血压(BP)水平分级,危险分层及诊断性评估等建议作一简要介绍【关键词】高血压定分层诊断性评估【Abstract】Thisarticlereviewsepidemiologicalstat...
医源资料库;在线期刊;中华实用医药杂志;2008年第8卷第7期MappingResiduesintheLigand-BindingDomainofthe5-HT3Receptorontod-TubocurarineStructure
【关键词】MappingResiduesTheserotonin5-HT3receptor(5-HT3R)isamemberofthecys-loopligand-gatedionchannelfamily.Wehaveusedthecombinationofsite-directedmutagenesis,homologymodelingofthe5-HT3Rextracellulardomain,andliganddockingsimulationsasawaytomapthearchitectureofthe5-HT3Rligandbindingdomain.Muta...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第8期5-羟色胺与食欲抑制剂
5-羟色胺(5-hydroxytryptamine,5-HT)又称血清素(serotonin),是人体重要的活性物质,5-HT在突触间隙消除的方式是通过重摄取和酶降解两种机制,其中以重摄取为主,5-HT受体亚型非常多,并且分布极为广泛,所以,5-HT神经元无论...
合作平台;在线期刊;中华实用医药杂志;2004年第4卷第11期;药物临床